Do you need to cycle progesterone? In women that are younger 20s and 30s and are low and progesterone. Yes it makes sense to take the progesterone on cycle days 14 through 25 or 12 days out of the month that makes perfect sense. if you are a woman who is in mid 40s to late 40s or in menopause, there is absolutely no clinical evidence that you need to cycle your progesterone. As a matter of fact, why would you want the benefits of the progesterone only 12 days out of the month when you get sleep,