THE earliest lesions of certain types of experimental nephrocalcinosis involve the distal portions of the renal tubules and the collecting ducts. 1,2 Disturbances in renal tubular function might ...

HYPERCHLOREMIC acidosis is a characteristic feature of a variety of kidney diseases that have in common impairment of urinary acidification with the excretion of an alkaline urine. These disorders, ...

Renal tubular acidosis may signal subclinical kidney involvement in patients with mutations in the TTR gene, according to new research. Some 18.3% of the symptomatic and asymptomatic patients with TTR ...

Extract: This report concerns two patients with primary renal tubular acidosis (RTA) in whom the abnormality in hydrogen excretion was shown to result from inappropriate urinary loss of bicarbonate ...

The kidneys play a central role in maintaining systemic acid–base homeostasis by finely regulating the reabsorption of bicarbonate and the secretion of protons along the renal tubules. Central to this ...

BUDAPEST, Hungary — Sodium bicarbonate — long used, albeit sporadically, to correct metabolic acidosis in chronic kidney disease — is significantly better at slowing disease progression than standard ...