Endotoxin refers to a component of the outer cell membrane of Gram-negative bacteria called lipopolysaccharide (LPS). LPS is the biologically active portion of naturally occurring endotoxin complexes.

In early life, the innate immune system can recognize both viable and nonviable parts of microorganisms. Immune activation may direct the immune response, thus conferring tolerance to allergens such ...

Wood workers in well-established industries in developed countries have an increased risk for asthma and other respiratory diseases (Demers et al., 1997). Similar observations have been made in a ...

Inadequate endotoxin testing places patients at risk. Knowing the relative strengths and weaknesses of available test methods is crucial to maintaining quality and safety. Endotoxins are small, ...

Endotoxin removal from a finished product is a major challenge for biopharmaceutical manufacturers; particularly as all endotoxin removal methods have operational limitations and may result in loss of ...

Summary To determine the microbial content and endotoxin concentration in the water reservoirs of benchtop autoclaves used in general dental practice. Design The study was done in two stages. Firstly ...

Researchers at North Carolina State University have shown a link between the size of cockroach home infestations and the levels of both allergens and endotoxins in those homes, with lowering roach ...

THE role of bacterial endotoxins in the pathogenesis of infections due to endotoxin-containing bacteria is not clear. It is commonly assumed that endotoxin is a major factor in determining toxicity ...

In this episode of C&EN Uncovered, host Craig Bettenhausen speaks with C&EN assistant editor Laurel Oldach about the use of horseshoe crab blood in pharmaceutical endotoxin testing, the challenges of ...

Increasing concentrations of a highly purified bacterial lipopolysaccharide preparation, the U.S. Reference Standard Endotoxin, were exposed to increasing doses of ionizing radiation from a 60 Co ...

Have you ever wondered why endotoxin testing is crucial? Endotoxins are toxic substances found in the outer membrane of Gram-negative bacteria, and they can cause severe reactions in humans, including ...

Surf on a beach at sunset features a horseshoe crab upside down in the water and several others nearby. Regulatory changes may make the pharmaceutical industry less reliant on horseshoe crabs for ...