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Brock Purdy threw for 303 yards and three touchdowns as San Francisco is now one win away from earning the NFC's top seed.
USA Today's NFL experts make their picks for a Week 18 showdown between the San Francisco 49ers and Seattle Seahawks
The NFC West and the top overall seed in the conference is on the line Saturday at Levi’s Stadium when the San Francisco 49ers (12-4) host the Seattle Seahawks (13-3). Sam Darnold and the Seahawks have won six in a row to take a one game lead into the final game of the regular season.
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49ers playoff scenarios: What a win or loss vs. Seahawks means for San Francisco
Saturday night's matchup between the San Francisco 49ers and Seattle Seahawks is straightforward at the top: the winner clinches the NFC West title and home-field advantage throughout the NFC playoffs.